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VC2.2.2: An antibody fragment that blocks the binding of VEGF-C to

VEGF-Receptors

 
 

In a nutshell, vascular endothelial growth factor-C (VEGF-C) is a proteinaceous growth factor that binds to its receptors VEGF-receptors 2 and 3, activates them and thereby induces the growth of new lymphatic vessels from pre-existing lymphatic vessels (lymphangiogenesis).


 

What is VEGF-C?

Ribbon-modell of the human VEGF-C dimer (pdb file 2X1X, Leppanen et al)

Why is VEGF-C important?

Certain cancer types preferably metastasize via lymphatic vessels. Cancer cells from e.g. melanoma express lymphangiogenic growth factors like VEGF-C which induces the growth of lymphatic vessels around the primary tumor site. The cancer then invades the lymphatic vessels and disseminates metastatic cancer cells that travel to local lymph nodes, distant lymph nodes and finally distant organs to establish metastases. Metastasized cancer is more difficult to treat and is a sign of advanced disease.